Tony Romo and the Cowboys dealt a defending champion an opening loss for first time since 1999.

Eli Manning throws for 510 yards as the Giants edge the Buccaneers.

Torrey Smith excelled on the day after his brother died in a motorcycle accident.

Right when it appeared the Packers' season would spiral out of control, Aaron Rodgers saw his team to a pivotal win.

In addition to breaking a long-standing record, Drew Brees lifted the Saints to their first win of the season.

Facing a 24-0 deficit at halftime, the Broncos scored 35 unanswered points to win.

Victor Cruz scored a 77-yard touchdown to lift the Giants past the Redskins.

Jay Cutler helped the Bears overcome a 19-7 fourth-quarter deficit to defeat the Panthers.

Isaac Redman scored the winning touchdown to cap a fourth-quarter Steelers surge past the host Giants.