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  • Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression
  • The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove
  • dJun and Vri/dNFIL3 Are Major Regulators of Cardiac Aging in Drosophila
  • Loss of the DNA Methyltransferase MET1 Induces H3K9 Hypermethylation at PcG Target Genes and Redistribution of H3K27 Trimethylation to Transposons in Arabidopsis thaliana
  • A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease
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Review

Lessons from Model Organisms: Phenotypic Robustness and Missing Heritability in Complex Disease

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In this Review, Christine Queitsch and colleagues describe the causes and consequences of decreased phenotypic robustness in model organisms, relate these findings to complex disease phenotypes, and propose an alternative GWAS approach that accounts for differences in robustness among humans.

 

Featured Research

A Novel Human-Infection-Derived Bacterium Provides Insights into the Evolutionary Origins of Mutualistic Insect–Bacterial Symbioses

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These results show that genome degeneration proceeds rapidly following the onset of symbiosis. They also highlight the potential for diverse insect taxa to acquire closely related insect symbionts as a consequence of vectoring bacterial pathogens to plants and animals.

 

The Contributions of Wobbling and Superwobbling to the Reading of the Genetic Code

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The authors find that superwobbling occurs in all codon families where it is theoretically possible, demonstrating that all triplets with pyrimidines in third codon position are dually decoded: by a tRNA utilizing standard base pairing or wobbling and by a second tRNA employing superwobbling.

 

A Unified Method for Detecting Secondary Trait Associations with Rare Variants: Application to Sequence Data

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These authors developed a unified method for detecting secondary trait associations with rare variants (STAR) in selected and random samples, which can flexibly incorporate all rare variant association tests and allow joint analysis of multiple cohorts ascertained under different study designs.

 

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PLOS Biology; PLOS Medicine; PLOS Computational Biology; PLOS Genetics; PLOS Pathogens; PLOS ONE; PLOS Neglected Tropical Diseases

November 2012 Issue

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PLOS Genetics is a peer-reviewed, open-access journal that reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.

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