Ule
Laboratory

Post-transcriptional regulatory networks


New!

On 1st of April, the lab will move to University College London, Faculty of Brain Sciences.

We will join the Department of Molecular Neuroscience at the Institute of Neurology.


Messenger RNA (mRNA) carries the genetic information from DNA to the machinery in our cells that makes the proteins. As it travels through the different parts of the cell, an mRNA needs to pass through several regulatory stages. These stages are controlled by RNA-binding proteins (RBPs) and non-coding RNAs, which interact with the mRNA and pre-mRNA. The positioning of RBPs is determined by the sequence and structure of each RNA, therefore each RNA assembles into a unique regulatory ribonucleoprotein complex (RNP). These regulatory RNPs are very dynamic, therefore we study them in intact cells and tissues, employing functional genomics and protein engineering technologies.

Our work aims to:

1) Determine how the regulatory RNPs control pre-mRNA processing and protein translation.

2) Understand how the regulatory RNPs respond to cellular signals, in particular during stress.

3) Define the disease-causing mechanisms of mutations that perturb the regulatory RNPs, with a focus on cancer and neurodegeneration.

As an RNA passes through the cellular regulatory stages, it is like a character from Mozart's Magic Flute, passing through the ordeals of space and time. And here are some of the RNA stories that we have passed through:

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