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Oncogenes induce a reversal of replication’s fortunes
Neelsen et al. describe how certain oncogenes can perturb DNA replication and induce DNA damage.Several oncogenes, including Cyclin E and Cdc25A, push cells precipitously…
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CUL4B keeps replication firing on all cylinders
Zou et al. describe how a protein linked to mental retardation promotes DNA replication.Mutations in CUL4B, a member of the cullin family of ubiquitin…
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miR-612 suppresses HCC metastasis
MicroRNAs (miRNAs) play a critical role in tumor metastasis. In this study, we identified a set of 32 miRNAs involved in hepatocellular carcinoma (HCC)…
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A2AR–mGluR5 interaction on BMDCs
The bone marrow–derived cell (BMDC)–associated inflammatory response plays a key role in the development of acute lung injury (ALI). Activation of adenosine A2A
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biobytes: March 4, 2013
In the March 4th edition of biobytes, Sachiyo Kawamoto (NIH, Bethesda, MD) explains how an RNA-binding protein promotes neuronal differentiation (Kim et al.), and Rosa Puertollano (NIH, Bethesda, MD) describes the regulation of a transcription factor...(more)
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biosights: February 18, 2013
Cell division requires the coordinated action of proteins that promote actomyosin contraction, membrane trafficking, and extracellular matrix remodeling. Wloka et al. reveal that, in budding yeast, the type II myosin Myo1 acts as an immobile scaffold... (more)
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