Neptune 96

New Pipettor brochure draft An air-filled single-channel hand Pipettor and semi-automated 96-channel pipettor that are the world’s first to do discrete sample transfer down to nanoliters contact-free with disposable tips. Powered by our patented core technology, they offer both extremely fine resolution and high flow/volume, enabling its user to precisely aspirate as little as 250 nanoliters and deliver it contact-free. Perfect for small analytical labs as well as high-throughput screening (HTS) and pharmaceutical applications.

Neptune 96 also features an intuitive graphical user interface with a pre-programmed set of pipetting programs that also serve as useful templates when developing other custom applications for diagnostic kits, reagent sequences or sample prep.

Titan

A fully-automated liquid handling system with a precise 3-axis robotic arm. Powered by our patented core technology, Titan can use our Dual Resolution Syringes and other pumps, all of which offer both extremely fine resolution and high flow/volume. With Dual Resolution Syringe Longstroke, the TITAN system has a 250-fold resolution multiplier. In addition, Titan can: accurately deliver to all 1536 wells of a microplate; precisely target a MALDI chip with as little as 250 nanoliters; and touchoff with as little as 50 nanoliters in any type of array.

Titan also features an intuitive graphical user interface with a pre-programmed set of sophisticated operations. These programs serve as useful templates when developing custom applications for virtually any diagnostic kit, reagent sequence or sample prep.

Little Squirt

A compact precision liquid handling system that can replace an array of traditional handheld micro- and nano-pipettors. Powered by our patented core technology, Little Squirt offers both extremely fine resolution and high flow/volume, with a robust 200-fold resolution multiplier. The smart hand probe works with standard disposable tips, making it ideal for navigating into tiny vials and diluting or mixing precious small samples en-route to a PCR plate or large analyzer. It can even accurately target MALDI spacing and small arrays.

Little Squirt’s integrated software and intuitive user interface allow you to hit the ground running with a pre-programmed set of sophisticated operations. These programs serve as useful templates when developing custom applications for virtually any diagnostic kit, reagent sequence or sample prep.

Dual Resolution Syringe (DRS)

Replace a standard syringe with a DRS™ Pump Module and instantly handle much smaller samples with much greater precision while simultaneously delivering far greater flow/volume for contact-free delivery and extreme dilutions. Powered by our patented core technology, DRS™ Pump Modules are ideal for syringe pumps, diluters, and automated systems with banks of traditional syringes with either lower-limit restrictions or reliability issues.

DRS™ Pump Modules also feature an intuitive graphical user interface with a pre-programmed set of sophisticated operations. These programs serve as useful templates when developing custom applications for virtually any diagnostic kit, reagent sequence or sample prep.

DRS™ Converter Kit

Replace the standard syringe you are using with your Hamilton Microlab 500 (or similar diluter or dispenser) with a Dual Resolution Syringe and instantly handle much smaller samples with much greater precision while simultaneously delivering much greater flow for contact-free delivery and extreme dilutions. Powered by our patented core technology, this DRS conversion will give your unit a veritable rocket boost.

All DRS™ products come with an intuitive graphical user interface with a pre-programmed set of sophisticated operations. These programs serve as useful templates when developing custom applications for virtually any diagnostic kit, reagent sequence or sample prep.

Software Peripherals Control

Our Visual Basic software was designed to make it easy to add other peripheral devices and integrate their command control.

Rugged Durability

No small piston or small seal whatsoever — you can see that the pistons and seals are obviously much stouter and more rugged than those in a small syringe.  All Longstroke products therefore can meter substantial volumes and have very clean high flow. This all manifests as real operational robustness on every level.  But extraordinary fine resolution is built right in with this because of our Differential DisplacementTM invention and design.  A remarkable combination.

Ultra-Fine Resolution

Two rugged pistons moving together give you ultra-fine resolution by our patented Differential DisplacementTM without any small piston or seal whatsoever.

Wide Dynamic Range

Our patented Differential DisplacementTM means that both pistons moving together within the one chamber give you ultra-fine resolution but that one piston moving alone gives you huge flow and volume, hence the Dual ResolutionTM feature that also gives you unprecedented wide dynamic range.

Unprecedented Precision

The large excursion range or Stroke (hence “Longstroke”) of our patented Differential Displacement™ mechanism is readily visible to your eye during operation and absorbs external errors and reduces variance to give consistent precision and accuracy.

Adjustable Tip Escape Velocity (TEVIA)

Our patented core technology provides built-in abundant flow-power reserve to call on for vigorous dispensing or contact-free escape of sample or reagent from the tip. Only we dare to invite you to see directly throughout operation exactly what the meters per second speed is of liquid leaving your tip. We invented the concept of Tip Escape Velocity In Articulatum.

Intuitive User Interface

We have used the things computers and humans do best to make an intuitive and common-sense interface that lets you decide to pull and push functions directly or to call on total automation.

Microfluidic chips

Feeding microfluidic chips.  The tip  (disposable or fixed)  moves precisely to the entry port of a microfluidic chip.  The desired volume of liquid is deposited in the port, either by contact-free blastoff or by touchoff.  The deposited liquid may be sucked into the chip’s channels or moved through by electrical charges or other means. Or, via a coupling contact, the Longstroke technology can actively infuse the sample through the chip at a desired speed, from fast to extremely slow, oscillating or pulsatile-free.

Arrays

50 nanoliters is precisely extruded by Titan from DRS 3.3/330 (aka DRS Blue) in its ultrafine Differential Mode and then touched off to a slide. The spacing is 1.11 mm apart, as in a 6144 well microplate). Program CP851.

Polymerase Chain Reaction (PCR)

The polymerase chain reaction (PCR) is a scientific technique used in molecular biology to amplify one or more copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence.

Matrix-Assisted Laser Desorption Ionization (MALDI)

When pipetting very tiny amounts of liquids with a traditional syringe, it is impossible to then generate the high flow volume needed for contact-free delivery. Most automated systems cannot perform this task with volumes less than 10 uL, which means that samples must be diluted with costly reagents and disposed of in an expensive waste stream. The Dual-Resolution Syringe™ overcomes this challenge using Differential Displacement, which allows it to precisely aspirate tiny samples down to nanoliters and then change to the Single mode to deliver the necessary Tip Escape Velocity (TEVIA) to deliver them contact-free.

High-Throughput Screening (HTS)

High-Throughput Screening allows researchers to quickly conduct a large number of chemical, genetic or pharmacological tests. Through this process one can rapidly identify active compounds, antibodies or genes which modulate a particular biomolecular pathway. The results of these experiments provide starting points for drug design and for understanding the interaction or role of a particular biochemical process in biology.

Contact-Free Delivery

When pipetting very tiny amounts of liquids with a traditional syringe, it is impossible to then generate the high flow volume needed for contact-free delivery. Most automated systems cannot perform this task with volumes less than 10 uL, which means that samples must be diluted with costly reagents and disposed of in an expensive waste stream. The Dual-Resolution Syringe™ overcomes this challenge using Differential Displacement, which allows it to precisely aspirate tiny samples down to nanoliters and then reach the necessary Tip Escape Velocity (TEVIA) to deliver them contact-free.

Rescuing Short Samples

Titan easily aspirates the required 10uL of DNA eluant from just 15 uL in a small microcentrifuge tube, rather than the 100 uL minimum starting volume called out by many assays. Example is from FVL (Factor V Leiden).

DNA Eluant Short Sample Aspiration

Molecular biology and DNA-related procedures often call for at least 100 uL of starting material, such as DNA eluant, so that the various semi-manual procedures of aspirating that material can get the 10 uL minimum required. TITAN with DRS, however, easily asirates the needed 10uL from even 15 uL of starting material in a small microcentrifuge tube. Same for Little Squirt. The white holders for the microcentrifuge tubes were developed by DRS Longstroke to facilitate this.

DNA Eluant Transfer

Titan easily automatically aspirates from very small starting volumes of DNA and molecular biology related materials and transfers. This video shows Titan aspirating the 10 uL of DNA eluant called out for this procedure (Factor V Leiden using Third Wave reagents), with a precision of far less than 1% CV, and delivering them to the PCR plate.

Master Mix Preparation

Master Reagent Mixes must be prepared for many molecular biology and DNA-related procedures. In this case (FVL, or Factor V Leiden), 10 uL of each of six different molecular reagents must be combined. The assay is apparently robust enough to allow the precision involved in the hand-pipetting typically used for each sample. But Titan and DRS here aspirate the 10 uL with way less than 1% precision– around 0.2% precision — producing a Master Mix that is far more precise and consistent than required. This capability of TITAN and the DRS should be able to be exploited to improve the assay as well as dramatically reduce the volume of reagent and DNA eluant required.