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JGP articles are published online before print. The date of online release is posted on each article and is the official date of publication. Learn more about JGP Early Release Articles.
April 27, 2015
News
Generally Physiological
- Elizabeth M. Adler
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Thinking of calcium and fleeing flies
Commentaries
- Bernhard E. Flucher
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- Michael C. Puljung
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How is SR calcium release in muscle modulated by PIP(4,5)2?
New structural insights into the gating movements of CFTR
Research Articles
- Roshni V. Madhvani,
- Marina Angelini,
- Yuanfang Xie,
- Antonios Pantazis,
- Silvie Suriany,
- Nils P. Borgstrom,
- Alan Garfinkel,
- Zhilin Qu,
- James N. Weiss,
- and Riccardo Olcese
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- Osama F. Harraz,
- Frank Visser,
- Suzanne E. Brett,
- Daniel Goldman,
- Anil Zechariah,
- Ahmed M. Hashad,
- Bijoy K. Menon,
- Tim Watson,
- Yves Starreveld,
- and Donald G. Welsh
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- Balázs Tóth,
- Iordan Iordanov,
- and László Csanády
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- Carmen A. Ufret-Vincenty,
- Rebecca M. Klein,
- Marcus D. Collins,
- Mario G. Rosasco,
- Gilbert Q. Martinez,
- and Sharona E. Gordon
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- Wenjun Zheng and
- Feng Qin
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Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations
J Gen Physiol 2015 145:395-404. Published April 27, 2015, doi:10.1085/jgp.201411288
Decreasing the amplitude of the late component of the cardiac L-type Ca2+ channel current suppresses early afterdepolarizations, thereby decreasing the risk of arrhythmias.
CaV1.2/CaV3.x channels mediate divergent vasomotor responses in human cerebral arteries
J Gen Physiol 2015 145:405-418. Published April 27, 2015, doi:10.1085/jgp.201511361
Human cerebral arteries contain three Ca2+ channel subtypes with distinct physiological roles.
Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2′-phosphate
J Gen Physiol 2015 145:419-430. Published April 27, 2015, doi:10.1085/jgp.201511377
ADP-ribose-2′-phosphate acts as a direct agonist of TRPM2, whereas NAD, NAAD, and NAADP do not.
Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels
J Gen Physiol 2015 145:431-442. Published April 27, 2015, doi:10.1085/jgp.201511354
Phosphoinositides bind to a selective site in the proximal C-terminal region to regulate TRPV1.
A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activation
J Gen Physiol 2015 145:443-456. Published April 27, 2015, doi:10.1085/jgp.201411335
Coarse-grained modeling and all-atom molecular dynamics simulation provide insight into the mechanism for heat activation of TRPV1 gating.
April 13, 2015
Perspectives
- Olaf S. Andersen
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- Frederick Sachs and
- Mettupalayam V. Sivaselvan
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- Janet M. Wood
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- Elizabeth S. Haswell and
- Paul E. Verslues
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Perspectives on: The response to osmotic challenges
Perspectives on: The response to osmotic challenges Cell volume control in three dimensions: Water movement without solute movement
Perspectives on: The response to osmotic challenges Bacterial responses to osmotic challenges
Perspectives on: The response to osmotic challenges The ongoing search for the molecular basis of plant osmosensing
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