Science, December 24, 2010
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
Science, December 24, 2010
Major Findings from the modENCODE project
Unlocking the Secrets of the genome
Nature, June 18, 2009
Grants Home On Other Sites: The ENCODE (ENCylopedia Of DNA Elements) Project.
Science, October 22, 2004
The modENCODE Project
modMINE data warehouse
The modENCODE Project: Model Organism ENCyclopedia Of DNA Elements (modENCODE)
- Overview
- Publications and Press Releases
- Consoritum Membership
- modENCODE Data Release Policy
- Requests for Application (RFAs)
- Program Staff
modENCODE Overview
The modENCODE Project, Model Organism ENCyclopedia Of DNA Elements, was initiated by the funding of applications received in response to Requests for Applications (RFAs) HG-06-006, entitled Identification of All Functional Elements in Selected Model Organism Genomes and HG-06-007, entitled A Data Coordination Center for the Model Organism ENCODE Project (modENCODE). The modENCODE Project is being run as an open consortium and welcomes any investigator willing to abide by the criteria for participation that have been established for the project.
Both computational and experimental approaches are being applied by modENCODE investigators to study the genomes of D. melanogaster and C. elegans. An added benefit of studying functional elements in model organisms is the ability to biologically validate the elements discovered using methods that cannot be applied in humans. The comprehensive dataset that is expected to result from the modENCODE Project will provide important insights into the biology of D. melanogaster and C. elegans as well as other organisms, including humans.
modENCODE Consortium members published the most significant findings from the project so far in two integrative analysis papers that appeared in Science on December 24, 1010. Both the C. elegans and D. melanogaster integrative analysis papers are available through open-access. These papers evaluate the success of modENCODE in identifying a comprehensive set of functional genome elements in each species. Several companion papers are also published in Genome Research, Genome Biology, and Nature. Read more about the integrative analysis papers and companion papers.
The modENCODE Data Coordination Center (DCC) maintains databases to track, store, and provide access to data generated as part of the modENCODE Project and other related projects. It maintains browsers for the D. melanogaster and C. elegans genomes and hosts a public website [modencode.org] that allows members of the scientific community to learn about the modENCODE Project and provide input into the prioritization of certain project activities. The DCC also maintains a data warehouse, modMINE [modmine.org], that allows sophisticated queries of the modENCODE data.
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modENCODE Publications and Press Releases
Publications
- Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
Science, December 24, 2010 - Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
Science, December 24, 2010 - Companion papers for each of these are published in Nature, Genome Research, and Genome Biology:
- Genome 'census' reveals hidden riches
Nature, December 22, 2010
- Comprehensive analysis of the chromatin landscape in Drosophila melanogaster
Nature, December 22, 2010 - The developmental transcriptome of Drosophila melanogaster
Nature, December 22, 2010
- Selected Abstracts
Genome Research, December 22, 2010
- Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2
Genome Biology, December 23, 2010
- Genome 'census' reveals hidden riches
- Unlocking the Secrets of the Genome
Nature, June 18, 2009
Press Releases
- Scientists reveal how biological activity is regulated in fruit fly and roundworm genomes
December 22, 2010 - Fly and Worm Models to Teach Researchers About Human Biology and Medicine
May 14, 2007
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modENCODE Consortium Membership
- modENCODE Participants and Projects
- modENCODE Data Coordinating Center [modencode.org]
- Criteria for Participation
- External Consultants Panel
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modENCODE Data Release Policy
NHGRI has designated the modENCODE Project as a community resource project to accelerate access to and use of the data by the entire scientific community. Accordingly, the data release policy is based on the principles of rapid data release to the scientific community set forth in the Fort Lauderdale agreement on Sharing Data from Large-scale Biological Research Projects.
- ENCODE-modENCODE Consortia Data Release Policy (2008-Present)
- Ft. Lauderdale Agreement on Sharing Data from Large-scale Biological Research Projects: A System of Tripartite Responsibility
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modENCODE Requests for Application (RFAs)
Past modENCODE RFAs
- RFA-HG-06-006 [grants.nih.gov]: Identification of All Functional Elements in Selected Model Organism Genomes (Expired)
- RFA HG-06-007 [grants.nih.gov]: A Data Coordination Center for the Model Organism ENCODE Project (modENCODE) (Expired)
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modENCODE Program Staff
Program Directors
Elise Feingold, Ph.D.
E-mail: feingole@exchange.nih.gov
Peter Good, Ph.D.
E-mail: goodp@mail.nih.gov
Michael Pazin, Ph.D.
E-mail: pazinm@mail.nih.gov
Program Analysts
Leslie Adams
E-mail: adamslb@mail.nih.gov
Caroline Kelly
E-mail: caroline.kelly@nih.gov
Address
National Human Genome Research Institute
National Institutes of Health
5635 Fishers Lane
Suite 4076, MSC 9305
Bethesda, MD 20892-9305
Phone:(301) 496-7531
Fax:(301) 480-2770
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Last Updated: October 3, 2011
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