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Clinical Studies

J. A. DIPALMA, J. MCGOWAN, M. Vb. CLEVELAND. Clinical Trial: an efficacy evaluation of reduced bisacodyl given as part of a polyethyleneglycol electrolyte solution preparation prior to colonoscopy.  Aliment Pharmacol Ther 26, 1113-1119.

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HalfLytely and Bisacodyl Tablets Bowel Prep Kit is a gastrointestinal lavage indicated for cleansing of the colon as a preparation for colonoscopy in adults. Most common adverse reactions (<3%) are abdominal pain/cramping, nausea, vomiting and headache. Use is contraindicated in the following conditions: known allergies to polyethylene glycol or other components of the kit, gastrointestinal (GI) obstruction, bowel perforation, toxic colitis, toxic megacolon.

Use with caution in patients using concomitant medications (such as diuretics) that increase the risk of electrolyte abnormality, patients with known or suspected hyponatremia, patients with severe ulcerative colitis, ileus or gastric retention. There have been reports of ischemic colitis in patients with use of HalfLytely and 20 mg Bisacodyl Tablets Bowel Prep Kit. However, a causal relationship has not been established. If patients develop severe abdominal pain or rectal bleeding, patients should be evaluated as soon as possible. Patients with impaired water handling who experience severe vomiting should be closely monitored including measurement of electrolytes. Hives and skin rashes have been reported with PEG-based products which are suggestive of an allergic reaction.

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