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  • Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity against Streptococcus pneumoniae
  • Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens
  • Phenoloxidase Activity Acts as a Mosquito Innate Immune Response against Infection with Semliki Forest Virus
  • Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions
  • The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18
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Featured Review

Vaccines: From Empirical Development to Rational Design

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Vaccine development is often rendered difficult due to immune escape and evasion by pathogens. Furthermore, most currently available vaccines were empirically designed. In this review, Rueckert and Guzmán discuss why rational design of vaccines is not only desirable but also necessary.

 

Featured Pearls

A Wolf in Sheepโ€™s Clothing: SV40 Co-opts Host Genome Maintenance Proteins to Replicate Viral DNA

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Shortly after its discovery, Simian virus 40 (SV40) was adopted as a model to study eukaryotic genome structure, expression, replication and cell growth regulation in cultured cells. Sowd and Fanning discuss how SV40 heavily relies on host cell machinery to propagate, thus providing researchers with a tool to discover key host proteins that the virus manipulates.

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Featured Research

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

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Genetic studies have shown that ROP5, a pseudokinase which controls pathogenesis of Toxoplasma gondii in the mouse, is essential for acute virulence but its mechanism of action has remained uncertain. Behnke et al. demonstrate that ROP5 regulates the active protein kinase ROP18, which normally prevents clearance of the parasite in interferon-activated macrophages.

 

Genome Structure and Reproductive Behaviour Influence the Evolutionary Potential of a Fungal Phytopathogen

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Leptosphaeria maculans, a fungal pathogen, develops gene-for-gene interactions with its host plant, and has a high evolutionary potential to render ineffective novel sources of crop resistance. Daverdin et al. suggest that increased mutability of fungal genes involved in plant interactions is directly related to their genomic environment and reproductive system.

 

Early Mechanisms of Pathobiology Are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice

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Central to neurodegenerative disease, under which prion disorders are grouped, is progressive synaptic impairment that leads to the irreversible loss of neurons. By investigating neurons early in disease, Majer et al. demonstrate the activation of a transcriptional program indicative of a protective mechanism which diminishes as disease progresses.

 

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October 2012 Issue

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PLOS Pathogens is an open-access journal that publishes important new ideas on bacteria, fungi, parasites, prions, and viruses that contribute to our understanding of the biology of pathogens and pathogen-host interactions.

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