Editors' Choice

Neuroimmunology
Neuronal Rewiring by Blood Vessels

Wei Wong
20 November 2012: ec296.
Promoting angiogenesis may increase recovery of motor function in individuals with multiple sclerosis. Abstract »|  

Vascular Biology
A Valve for Nitric Oxide

Ernesto Andrianantoandro
20 November 2012: ec297.
The oxidation state of hemoglobin α in myoendothelial junctions controls delivery of nitric oxide. Abstract »|  

Developmental Biology
Dishevelled Mediates Wnt-Notch Crosstalk

Annalisa M. VanHook
20 November 2012: ec298.
Dishevelled inhibits Notch signaling by preventing the formation of transcriptional activator complexes. Abstract »|  

Cell Biology
Directing Receptors into Cilia

Nancy R. Gough
20 November 2012: ec299.
SUMOylation of the guanosine triphosphatase ARL13B is required for proper targeting of sensory receptors into primary cilia. Abstract »|  

Cancer
Tumorigenic Targets of IKK

Nancy R. Gough
20 November 2012: ec300.
The kinase IKK promotes oncogenic signaling by phosphorylating the adaptor TRAF2. Abstract »|  

Cell Biology
Getting Autophagy to Akt

L. Bryan Ray
20 November 2012: ec301.
A direct link between a cancer-promoting protein kinase and the control of autophagy is presented. Abstract »|  

Podcasts

G Protein-Coupled Receptors
Science Signaling Podcast: 20 November 2012

Robert J. Lefkowitz and Annalisa M. VanHook
20 November 2012: pc26.
The 2012 Nobel Prize in Chemistry honors research on the function of G protein–coupled receptors. Abstract »|   Full Text »|   Podcast »|  

Research Articles

Computational Biology
Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage

Minsoo Choi, Jue Shi, Sung Hoon Jung, Xi Chen, and Kwang-Hyun Cho
20 November 2012: ra83.
State-space analysis of the p53 network identifies a therapeutic strategy for treating cancer. Editor's Summary »|   Abstract »|   Full Text »|   PDF »|   Supplementary Materials »|  

Channels
SUMOylation Silences Heterodimeric TASK Potassium Channels Containing K2P1 Subunits in Cerebellar Granule Neurons

Leigh D. Plant, Leandro Zuniga, Dan Araki, Jeremy D. Marks, and Steve A. N. Goldstein
20 November 2012: ra84.
Potassium channels that respond to acidification and the anesthetic halothane become electrically silenced when SUMOylated. Editor's Summary »|   Abstract »|   Full Text »|   PDF »|   Supplementary Materials »|  

Physiology
GPRC5B Activates Obesity-Associated Inflammatory Signaling in Adipocytes

Yeon-Jeong Kim, Takamitsu Sano, Takuji Nabetani, Yoshimi Asano, and Yoshio Hirabayashi
20 November 2012: ra85.
Mice lacking an orphan G protein–coupled receptor show reduced inflammatory signaling and obesity. Editor's Summary »|   Abstract »|   Full Text »|   PDF »|   Supplementary Materials »|  

Perspectives

Biochemistry
Sequential Conformational Rearrangements Dictate the Dynamics of Class C GPCR Activation

J. Robert Lane and Meritxell Canals
20 November 2012: pe51.
Fluorescent probes reveal the roles of domain rearrangement and dimerization in GPCR activation. Abstract »|   Full Text »|   PDF »|