- The Ortholog Conjecture Is Untestable by the Current Gene Ontology but Is Supported by RNA Sequencing Data
- Kinetics of Amyloid Aggregation: A Study of the GNNQQNY Prion Sequence
- Universal Pacemaker of Genome Evolution
- Weakly Circadian Cells Improve Resynchrony
- Temporal Expression-based Analysis of Metabolism
- Browse all recently published articles
Software
Software articles highlight and describe outstanding open source software of exceptional importance that has been shown to provide new biological insights. Since the first article was published in PLOS Computational Biology in August 2011, the section has been gathering momentum and this month we introduce a new collection gathering the published articles together for the first time.
For further information about the collection, check out this Editorial by PLOS Computational Biology Software Editors Andreas Prlić and Hilmar Lapp.
Perspective
Bioinformatics for the Human Microbiome Project
In this month's perspective, part of the Human Microbiome Project Collection, the authors discuss the history of the project and its computational components. Looking to the future, they also highlight the current major bioinformatics challenges and potential next steps in the field.
Featured Research
Simulations of Long-Term Community Dynamics in Coral Reefs - How Perturbations Shape Trajectories
The degradation of coral reefs is a major threat for tropical coastal environments. Here the authors present a spatially explicit model that may help to disentangle the combined effects of different perturbations and analyze their respective impact on the benthic community of a coral reef.
Sensorimotor Learning Biases Choice Behavior: A Learning Neural Field Model for Decision Making
In this study the authors ask how action selection mechanisms interact with the learning of new action choices. Their neurodynamic model explains electrophysiological findings from monkeys' sensorimotor cortex, and correctly predicted a newly described characteristic pattern of their choice errors.
Distinct Neurogenomic States in Basal Ganglia Subregions Relate Differently to Singing Behavior in Songbirds
Understanding how gene transcription relates to behaviour is challenging. In this study, Hilliard et al. apply a systems analytical approach to determine how thousands of genes change their expression levels simultaneously in the basal ganglia during a specific vocal-motor behavior, singing.
Image Credit: Peripitus Wikimedia Commons CC BY-SA
Other PLOS Content
PLOS Biology
- Sequencing the Connectome
November 2012 Issue
PLOS Computational Biology is a peer-reviewed, open-access journal featuring works of exceptional significance that further our understanding of living systems at all scales through the application of computational methods. It is an official journal of the International Society for Computational Biology.
ISCB
- The Roots of Bioinformatics in ISMB
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- A Report of the Curriculum Task Force of the ISCB Education Committee
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