The Epigenome Center, develops new experimental and computational methods for discovery through epigenomics, and informatics. The Epigenome Center aims to enable new discovery methodologies employing massively parallel sequencing and other high-throughput technologies.

The aim of the NIH Epigenomics Roadmap project is to understand the variation of epigenomes (methylation status, histone marks, chromatin accessibility) across major tissue types and experimentally relevant cell lines and to detect and interpret epigenomic variation due to a selected set of developmental, physiological, and disease processes. The project will produce a Human Epigenome Atlas. The Atlas contains epigenomic maps of major tissue types and experimentally relevant cell lines.