MetaCyc Overview

MetaCyc is a database of nonredundant, experimentally elucidated metabolic pathways. MetaCyc contains more than 1928 pathways from more than 2263 different organisms [more], and is curated from the scientific experimental literature. [more]

MetaCyc contains pathways involved in both primary [def] and secondary [def] metabolism, as well as associated compounds, enzymes, and genes. [more]

Motivations

The goal of MetaCyc is to catalog the universe of metabolism by storing a representative sample of each experimentally elucidated pathway. [MetaCyc mission]

MetaCyc is used in a variety of scientific applications, such as providing a reference data set for computationally predicting the metabolic pathways of organisms from their sequenced genomes, supporting metabolic engineering, helping to compare biochemical networks, and serving as an encyclopedia of metabolism. [scientific applications]

Recent Publication

The MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases, Nucleic Acids Research 40:D742-D753 2012.

Accessing MetaCyc Data

MetaCyc data can be accessed in several ways:

Search for pathways, enzymes, reactions, and metabolites through this Web site [more]
Install MetaCyc on your computer in conjunction with the Pathway Tools software for faster access and more query options [more]. This local installation also allows you to query MetaCyc programmatically using Java or PERL programs.
Download MetaCyc data files [more].

New Users

Get a bird's eye view of the MetaCyc web site here. MetaCyc survey. -->

How to Cite MetaCyc

Please cite MetaCyc as Caspi et al., 2012, "The MetaCyc Database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases", Nucleic Acids Research in publications resulting from its use.

Acknowledgments

The development of MetaCyc is funded by grant GM080746 from the NIH National Institute of General Medical Sciences and by grant DE-SC0004878 from the Department of Energy.

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