Research Papers

• Integrative eQTL-Based Analyses Reveal the Biology of Breast Cancer Risk Loci
• Genome-wide Association of Yorkie with Chromatin and Chromatin-Remodeling Complexes
• Adaptive evolution and the birth of CTCF binding sites in the Drosophila genome
• CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
• Robust and tunable circadian rhythms from differentially sensitive catalytic domains
• Integrated genomic analyses of ovarian carcinoma
• A cis-regulatory map of the Drosophila genome
• Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis
• A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult
• Orderly wheels of the cyanobacterial clock

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2013 REU Program in Systems Biology Research Experiences for Undergraduates

News

March 12, 2013

CBC announces a high throughput screening award

In response to the community-wide interest in High Throughput Screening, the CBC is offering a 1:1 HTS Matching Grant Program to help fund innovative small molecule discovery. The intent of this program is to support pilot projects involving bio medically-relevant targets using a HTS facility located at one of the CBC universities, including the IGSB’s Cellular Screening Center.  For more information see: chicagobiomedicalconsortium.org/grants/HTS_award.php

January 30, 2013

A network of nuclear receptors

By mapping the bindings sites of nuclear receptors, chromatin state markers and transcription factors associated with breast cancer, IGSB Director Kevin White and colleagues construct a network representing different types of regulatory relationships.  Their analyses identifies transcriptions factors with previously unsuspected roles in breast cancer and enables predictions of responses to therapy.

December 31, 2012

The inner workings of the circadian clock

Michael Rust and colleagues reveal the biochemical mechanisms that allow the oscillations of the cyanobacterial biological clock to be tuned to changes in the environment while simultaneously maintaining a robust 24-hour period. 

November 12, 2012

Tracing adaptive evolution of regulatory elements in the fly genome

Kevin White and colleagues determine the binding sites of the insulator protein CTCF in four Drosophila species whose divergence spans 25 million years in evolutionary time.  Their findings provide evidence for positive selection shaping the evolution of these regulatory sites and through them, the genes they control.

October 30, 2012

Argonne-Sponsored Meeting Showcases Scientific Advances in Soil Metagenomics

More than 140 researchers from the United States, Canada, Brazil, Asia (Taiwan), and Europe (Czech Republic, France, Germany, Spain) gathered at the Indian Lakes Resort near Chicago to participate in the 4th Annual Argonne Soil Metagenomics meeting October 3–5.

October 10, 2012

Systems Biology of Immune Cells at the Genomic Level

Aly Azeem Khan, IGSB/CBC Postdoctoral Fellow in the Institute for Genomics and Systems Biology, co-authored with collaborators at Genentech, Washington University, New York University, MD Anderson Cancer Center, and the Virginia Commonwealth University School of Medicine, a new study published online in advance of print in Science Magazine.

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2013 REU Program in Computational Neuropsychiatric Genomics Research Experiences for Undergraduates

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