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The cover images are from a symposium on Cys-loop ligand-gated ion channels and receptors published in this issue. Top row: ELIC and GLIC pentameric ligandgated ion channels (see Corringer et al. p. 565). Second row left: the rat pentameric a7 nicotinic ACh receptor (see Yakel, p. 597); and right: the architecture of the eukaryotic members of the pentameric ligand-gated ion channel superfamily, and a 5-HT3A/5-HT3B subunit chimaera (see Peters et al. p. 587); third row: the ACh receptor (see Auerbach, p. 573); bottom row: glycan, Cys-loop structure and internal hydration pocket in nicotinic ACh receptor channel gating (see Chen, p. 557)