Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

Jian Li; R. Alan Harris; Sau Wai Cheung; Cristian Coarfa; Mira Jeong; Margaret A. Goodell; Lisa D. White; Ankita Patel; Sung-Hae Kang; Chad Shaw; A. Craig Chinault; Tomasz Gambin; Anna Gambin; James R. Lupski; Aleksandar Milosavljevic

doi:10.1371/journal.pgen.1002692

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Open Access

Peer-reviewed

Research Article

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

Jian Li,

Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
R. Alan Harris,

Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Sau Wai Cheung,

Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Cristian Coarfa,

Affiliations: Bioinformatics Research Laboratory, Epigenome Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Mira Jeong,

Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Margaret A. Goodell,

Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Lisa D. White,

Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Ankita Patel,

Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Sung-Hae Kang,

Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Chad Shaw,

Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
A. Craig Chinault,

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