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STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function
• Robert P. Wilson,
• Megan L. Ives,
• Geetha Rao,
• Anthony Lau,
• Kathryn Payne,
• Masao Kobayashi,
• Peter D. Arkwright,
• Jane Peake,
• Melanie Wong,
• Stephen Adelstein,
• Joanne M. Smart,
• Martyn A. French,
• David A. Fulcher,
• Capucine Picard,
• Jacinta Bustamante,
• Stephanie Boisson-Dupuis,
• Paul Gray,
• Polina Stepensky,
• Klaus Warnatz,
• Alexandra F. Freeman,
• Jamie Rossjohn,
• James McCluskey,
• Steven M. Holland,
• Jean-Laurent Casanova,
• Gulbu Uzel,
• Cindy S. Ma,
• Stuart G. Tangye,
• and Elissa K. Deenick
Wilson et al. show that individuals with loss-of-function mutations in STAT3 have reduced numbers of peripheral blood MAIT and NKT cells, but not γδ T cells. Residual MAIT cells had normal expression of RORγt, but displayed impaired secretion of IL-17A and IL-17F.
J Exp Med jem.20141992. Published May 4, 2015, doi:10.1084/jem.20141992
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IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production
• Katrina Blazek,
• Hayley L. Eames,
• Miriam Weiss,
• Adam J. Byrne,
• Dany Perocheau,
• James E. Pease,
• Sean Doyle,
• Fiona McCann,
• Richard O. Williams,
• and Irina A. Udalova
Blazek et al. demonstrate that treatment with IL-28A reduces inflammation in collagen-induced arthritis by restricting the recruitment of IL-1β⁺ neutrophils.
J Exp Med jem.20140995. Published May 4, 2015, doi:10.1084/jem.20140995
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Replication of Plasmodium in reticulocytes can occur without hemozoin formation, resulting in chloroquine resistance
• Jing-wen Lin,
• Roberta Spaccapelo,
• Evelin Schwarzer,
• Mohammed Sajid,
• Takeshi Annoura,
• Katrien Deroost,
• Raimond B.G. Ravelli,
• Elena Aime,
• Barbara Capuccini,
• Anna M. Mommaas-Kienhuis,
• Tom O’Toole,
• Frans Prins,
• Blandine M.D. Franke-Fayard,
• Jai Ramesar,
• Séverine Chevalley-Maurel,
• Hans Kroeze,
• Abraham J. Koster,
• Hans J. Tanke,
• Andrea Crisanti,
• Jean Langhorne,
• Paolo Arese,
• Philippe E. Van den Steen,
• Chris J. Janse,
• and Shahid M. Khan
Lin et al. generate Plasmodium berghei mutants lacking enzymes critical to hemoglobin digestion. A double gene deletion mutant lacking enzymes involved in the initial steps of hemoglobin proteolysis is able to replicate inside reticulocytes of infected mice with limited hemoglobin degradation and no hemozoin formation, and moreover, is resistant to the antimalarial drug chloroquine.
J Exp Med jem.20141731. Published May 4, 2015, doi:10.1084/jem.20141731
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Corrections

RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development
• Rakesh Verma,
• Su Su,
• Donald J. McCrann,
• Jennifer M. Green,
• Karen Leu,
• Peter R. Young,
• Peter J. Schatz,
• Jeffrey C. Silva,
• Matthew P. Stokes,
• and Don M. Wojchowski
J Exp Med jem.2013062404242015c. Published May 4, 2015, doi:10.1084/jem.2013062404242015c
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A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia
• Michael A. McDevitt,
• Jianlin Xie,
• Shanmugasundaram Ganapathy-Kanniappan,
• Jason Griffith,
• Aihua Liu,
• Courtney McDonald,
• Philip Thuma,
• Victor R. Gordeuk,
• Christine N. Metz,
• Robert Mitchell,
• Jeffrey Keefer,
• John David,
• Lin Leng,
• and Richard Bucala
J Exp Med 2015 212:825. Published May 4, 2015, doi:10.1084/jem.2005239804172015c
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Perspective

Precision medicine: Clarity for the clinical and biological complexity of Alzheimer’s and Parkinson’s diseases
• Thomas J. Montine and
• Kathleen S. Montine
Alzheimer’s and Parkinson’s diseases, two of the most common neurodegenerative diseases, could benefit from optimally targeted and timed interventions tailored to individual patient disease. The topic is discussed in a perspective on precision medicine by Montine and Montine.
J Exp Med 2015 212:601-605. Published May 4, 2015, doi:10.1084/jem.20150656
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Brief Definitive Report

SIRT1 deacetylates RORγt and enhances Th17 cell generation
• Hyung W. Lim,
• Seung Goo Kang,
• Jae Kyu Ryu,
• Birgit Schilling,
• Mingjian Fei,
• Intelly S. Lee,
• Amanuel Kehasse,
• Kotaro Shirakawa,
• Masaru Yokoyama,
• Martina Schnölzer,
• Herbert G. Kasler,
• Hye-Sook Kwon,
• Bradford W. Gibson,
• Hironori Sato,
• Katerina Akassoglou,
• Changchun Xiao,
• Dan R. Littman,
• Melanie Ott,
• and Eric Verdin
Lim et al. demonstrate that protein deacetylase, Sirtuin 1, promotes autoimmunity by deacetylating RORγt increasing its transcriptional activity and promoting Th17 differentiation and function. Blockade or loss of Sirtuin 1 results in protection from multiple sclerosis-like disease in mice.
J Exp Med 2015 212:607-617. Published April 27, 2015, doi:10.1084/jem.20132378