Research
- Overview
- Initiatives
- Funding Opportunities
- Core Members
- Labs
- Research Papers
Papers Archive
- 2015
- 2014
- 2013
- 2012
- 2011
- 2010
- 2009
- 2008
- 2007
- 2006
- 2005
- 2004
- 2000
Orderly wheels of the cyanobacterial clock
by Michael Rust
Circadian rhythms, self-sustaining oscillations in an organism’s behavior that repeat roughly once per day, have fascinated biologists for hundreds of years (1, 2). Part of this fascination comes from the fact that the existence of intrinsic biological rhythms implies that an organism carries within it a model of how it expects the external world to behave—a plant that moves its leaves in anticipation of the sun even when grown in constant conditions must have some hard-wired knowledge of the rotation of the Earth. Fundamentally, these predictive biological rhythms must originate mechanistically from carefully regulated molecular interactions that generate oscillations. In PNAS, Chang et al. (3) present a series of cleverly designed structural and biochemical experiments that shed light on the inner workings of the best-defined biological clock, the KaiABC protein oscillator.
Commentary on: Chang Y-G, Tseng R, Kuo N-W, LiWang A (2012) Rhythmic ring–ring stacking drives the circadian oscillator clockwise. Proc Natl Acad Sci USA, 10.1073/pnas.1211508109 (www.pnas.org/content/109/42/16847.long)
Download
Research Papers
- Digital signaling decouples activation probability and population heterogeneity
E Life Sciences, 2015
- The microbe-mediated mechanisms affecting topsoil carbon stock in Tibetan grasslands
The ISME Journal, 2015
- Key metabolic pathways involved in xenobiotic biotransformation and stress responses revealed by transcriptomics of the mangrove oyster Crassostrea brasiliana
Aquatic Toxicology, 2015
- Hospital-associated microbiota and implications for nosocomial infections
Cell Press (Trends in Molecular Medicine), 2015
- Circadian rhythms: A protein fold switch joins the circadian oscillator to clock output in cyanobacteria
Science, 2015
- The ocean sampling day consortium
GIGA n Science, 2015
- Athletic equipment microbiota are shaped by interactions with human skin
Microbiome Journal, 2015
- Whole genome resequencing of experimental populations reveals polygenic basis of egg size variation in Drosophila melanogaster
Molecular Biology and Evolution, 2015
- Lifestyle evolution in cyanobacterial symbionts of sponges
mBio, 2015
- The role of the commensal microbiota in the regulation of tolerance to dietary allergens
Current Opinion in Allergy and Clinical Immunology, 2015
See all Research Papers