Biology for the post-genomic era
Genome Biology publishes research articles, new methods and software tools, in addition to reviews and opinions, from the full spectrum of biology, including molecular, cellular, organism or population biology studied from a genomic perspective, as well as sequence analysis, bioinformatics, proteomics, comparative biology and evolution.
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- Clare Garvey, PhD
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Articles
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Genome Biology 2012, 13:R9SIFT Indel
SIFT Indel is a method for predicting the effects of frameshifting indels in coding regions
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Genome Biology 2012, 13:R8Population-specific methylation
Measurement of TSS-proximal DNA methylation in CEU and YRI genomes reveals significant population specificity
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Genome Biology 2012, 13:415Crocodilian genome sequencing
An Open Letter describing the project to sequence the genomes of the saltwater crocodile, the American alligator and the Indian gharial
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Genome Biology 2012, 13:R7Regulatory element eQTLs
An analysis of eQTLs located in regulatory elements in the human genome
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Genome Biology 2012, 13:R6MetaMerge
An algorithm that reconciles metabolic network reconstructions into a single model
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Genome Biology 2012, 13:R5Uberon multi-species ontology
A description of the Uberon ontology tool that allows comparisons of genomic information across multiple animal phyla
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Genome Biology 2012, 13:R4SpliceGrapher
A tool that uses a priori information to optimize alternative splicing prediction from RNA-seq data
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Genome Biology 2012, 13:141RTK mosaic amplification
Li Ding highlights recent findings suggesting that tumor cells with different driver mutations may coevolve rather than compete during clonal evolution
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Comments
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Comment on: Sarikas et al. Genome Biology 2011, 12:220Note added in proof
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Comment on: Schaack et al. Genome Biology 2011, 11:R46NHEJ Vs homologous recombination
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Comment on: Wong et al. Genome Biology 2011, 8:R72Change of corresponding author's e-mail address
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Latest issue
The complete issue of Genome Biology Volume 13 Issue 1 is now available.
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Genome Biology podcast
To coincide with September's special issue, we talk with Jim Lupski, Jay Shendure, Elaine Mardis and Joris Veltman about the challenges of identifying disease genes using exome sequencing and whole genome sequencing.
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Gregory Petsko's column
The dog particle
In a big announcement suspiciously soon before their funding is renewed, canine researchers have news about the Briggs Noson
Featured free review
Dosage compensation and the global re-balancing of aneuploid genomes
The dosage-compensation systems that equalize X-chromosome expression between sexes exemplify the intricacies of compensating for differences in gene copy number.
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From the blog
- 31 January 2012
- From the Rhine to the Rift Valley: Human population genetics in Genome Biology
- 30 January 2012
- Genome Biology’s two-mile high epigenomic epiphanies
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Genome Biology on Twitter
Twitter updates
- SIFT Indel: a method for predicting the effects of frameshifting indels from Pauline Ng's lab t.co/EZ70P18v #genomics 10:16 AM yesterday
- Significant population-specific methylation identified in HapMap LCLs, matched in brain samples t.co/H2Jtp7gf #genomics 6:09 PM Feb 9th, 2012
- Application of SIFT Indel shows a gene's 1st frameshifting indel causes LOF, but 2nd is compensatory, restores function t.co/EZ70P18v 3:53 PM Feb 9th, 2012