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Virulence Attributes and Hyphal Growth of C. neoformans ...
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Genomic Variation in Rice: Genesis of Highly Polymorphic ...

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October 2006 Issue

PLoS Genetics reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology.

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Featured Review

Application of Genome-Wide Single Nucleotide Polymorphism Typing: Simple Association and Beyond

The International HapMap Project and the arrival of new technologies have made GW-SNP assay a realistic endeavor. This review discusses the potential uses and practical application of GW-SNP typing to identify genetic association in disease.

Editors' Picks

Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer

The first substantive paper from the Breast and Prostate Cancer Cohort Consortium, an international study designed to assess the effect of variation in genes that influence hormone production and activity on the risk of breast and prostate cancer.

The Role of DNA Double-Strand Breaks in Spontaneous Homologous Recombination in S. cerevisiae

Homologous recombination (HR) is a source of genomic instability and the loss of heterozygosity in mitotic cells. Lettier et al. have used a yeast-based system to investigate what types of DNA damage trigger HR most efficiently.

Mutation at the Evi1 Locus in Junbo Mice Causes Susceptibility to Otitis Media

The authors identified and characterized mouse mutants that demonstrate chronic otitis media (OM). One mutant, Junbo, which shares features with human OM, implicates a new gene involved in predisposition to this common disorder.

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