International Knockout Mouse Consortium - Knowledgebase

 

The search box offers many methods of searching the IKMC database. You can specify multiple search terms separated by spaces or commas. Each of these terms will be used to match genes in the database. The search terms are case insensitive, so "PAX6" is treated the same as "Pax6" by the search. ...

The IKMC database includes all genes from the Mouse Genome Informatics (MGI) database for which sequences and genome coordinates are available. This includes all genes predicted by the NCBI, Ensembl, and Vega (Vertebrate Genome Annotation) pipelines for mouse Genome Build 37. MGI continuously...

You can browse the IKMC database by selecting the "Browse" tab in the upper right of the screen. You are presented two options Browse by gene symbol Browse by chromosome Browsing by symbol separates the genes in the database by the first letter of the gene's official symbol. The...

Enter the gene symbol into the search box on the upper right and search. The resulting query summary lists one record (row) for each gene that matches your query. The Gene column displays the gene symbol, chromosome, and location. The Knockout Project Status column displays the current...

The answer to both questions is yes. IKMC welcomes gene nomination and prioritization requests from the research community. Please complete and submit the online gene nomination form www.knockoutmouse.org/startnom inategene. All submissions will be forwarded to and considered by the IKMC...

Due to the high-throughput nature of the IKMC efforts, no special efforts for individual genes can be pursued if there are experimental problems with the targeting effort for that gene. Therefore, it is currently difficult to provide production timelines . If successful, there is a 60% chance that...

Yes. For KOMP products go to the KOMP Repository website and search for your gene of interest using the Product Search box. For genes for which KOMP targeting is in progress, there will be a Register Interest link. Follow that link to register interest. You will receive email notification as soon...

The main emphasis of IKMC (as currently funded) is to generate targeting vectors and mutant ES cells. Only for a limited number of genes, mutant mice, embryos or sperm will be generated by the production centers. However, for KOMP, the KOMP Repository offers additional services, on a cost recovery...

To order IKMC products you can search the IKMC database and follow the order links on the gene status details page (see above). You can also access the different IKMC Repositories directly. To order KOMP products go to the KOMP Repository website and search for your gene of interest...

You can find this out yourself by following these steps: Type the name of a particular gene into the search window at www.knockoutmouse.org . For instance, searching for the gene 'Prmt1' will lead to this page: www.knockout mouse.org/search_results?crite ria=Prmt1 You...