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Open up and say Ahhhhhh to Oral Insulin
Posted Nov 10th 2006 10:52PM by Allie Beatty
Filed under: Type 1, Type 2, Childhood, Adult Onset, Drugs, Research, Products
Generex's flagship product, Oral-lynTM, is an oral insulin spray for the treatment of type 1 and type 2 diabetes. Their technology permits the delivery of insulin through the oral cavity (with no deposit in the lungs). Whatever you do, don't call it an inhaler.
Oral-lynTM is a liquid form of human insulin that is absorbed through the buccal mucosa. Say that three times, fast. It is delivered through the RapidMistTM device, which looks a lot like an inhaler. But because this device limits absorption to the mouth, there is no entry into the lungs. The rich vascularity of the buccal mucosa allows for much faster absorption of insulin and a shorter total duration of activity which makes Oral-lynTM an ideal mealtime insulin, as it can be conveniently administered immediately prior to meals with little prospect of hypoglycemia. Oral-lynTM can be used as a preventative agent by people with pre-diabetes to delay the onset of diabetes and by patients with type-2 diabetes to delay the onset of insulin dependence and the complications associated with diabetes.
Generex Oral-lynTM is expected to lead to an enormous improvement in the quality of life, with the elimination of pain and a significant increase in convenience. This will result in improved compliance with a relative decrease in complications and a significant reduction in the costs associated with treating them. Knowing now that you can non-invasively continuously monitor your blood sugars, patch on your basal rate, and puff (but not inhale) for your meals - I'm going to do my share of screaming from the hilltops to get these devices the attention they warrant.
Dear Mister FDA, please don't give any of these potential pipeline treatments any shenanigans. They deserve a bedtime story and a kiss on the forehead for the promise they bring to us in the cold, weary world of diabetes. Oh yeah-- and please put a little hustle in it! Yours truly, Allie B
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Reader Comments
(Page 1)1. Did not know! Thanks!
Posted at 6:47AM on Nov 11th 2006 by Fokk 0 stars
2. Thanks for the information!
Posted at 9:54AM on Nov 12th 2006 by Irvin 0 stars
3. Oral insulin is great and in fact convenient. I didn't know also, thanks.
Posted at 6:18PM on Nov 12th 2006 by Nicole 0 stars
4. Sorry folks, but this is basically an untested technology, that the folks at Generex couldn't get into Phase III trials in the good ol' USofA, so they ended up selling it to the people of (believe it or not!) Equador: see
diabetes.blog.com/197262/
Oral insulin available soon - in Equador
Generex's website says they're in late-stage clinical trials now, but doesn't have any press releases about any published data. And a search of PubMed didn't find any recent publications. Come on, Generex, if you're for real, let's see some published results, not just hype.
In other words, I wouldn't hold my breath...
Posted at 8:16PM on Nov 17th 2006 by Bill the DiabetesDoc 0 stars
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